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From the album Uncle Anesthesia. Played in standard tuning with a very Spanish-guitar feel. I recommend clean or light nothing more than a little overdrive. Main riff/verses high E5, D5, C5, B5 then... C5, B5 Chorus D5, C5, B5 Lead parts are in Em. That's pretty much it. By the way, "high E5" is in reference to either (12/14/14/x/x/x) (x/7/9/9/x/x). You can even play the horn parts if you want. It's all in the key of E. to the album for timing, etc. Great tune from a legendary band. Have fun with it and enjoy.